Science & Studies

Mechanism of Action

Pre-clinical research in animals has demonstrated the potent antioxidant properties of the PFB complex (PFBc) which include the upregulation of specific phase II detoxifying enzymes, a decrease in levels of reactive oxygen species (ROS), and increases in the level of intracellular glutathione.

In tissue culture studies, the PFB complex has been shown to markedly reduce oxidative stress in the cells and increase intracellular glutathione levels. This results in a significant decrease of reactive oxygen species and the degree of oxidative damage to the cell. Microarray studies have also shown that PFBc causes a significant increase and upregulation of specific phase II detoxifying enzymes including glutathione reductase and heme oxygenase.

Literature over the past 30 years has demonstrated the important role of oxidative stress in age related health conditions. The potent antioxidant properties of PFBc may support it’s role as an important antioxidant to preserve health.

Brain Health

The beta amyloid peptide appears to play a key role in the decrease of brain function over time. The aggregation of the β-amyloid peptide into oligomers and the formation of fibrils appear to be key events in the reduction of brain function.  Soluble oligomers of the β-amyloid peptide are neurotoxic and can cause neuronal cell death.

In several pre-clinical research studies in animals, PFB Complex (PFBc) has been shown to inhibit β-amyloid aggregation. The marked inhibitory effect of PFBc on β-amyloid aggregation has been demonstrated by: the Congo Red dye binding assay, Mass Spectrometry assays of aggregated peptide, and by 2-D Infrared spectroscopy.  Based on these studies, PFBc holds promise as a nutritional aid to good brain health.

Heart Health

Experimental studies in animals has found evidence that the PFB Complex induces increased levels of nitric oxide synthetase, which then generates higher levels of nitric oxide.  This nitric oxide has a direct effect on the smooth muscle cells in the muscularis layer of arteries and arterioles. The nitric oxide directly causes relaxation of the smooth muscle cells, which causes dilatation of the arterial and arteriolar vessels. This NO-induced vasodilation results in a lowering of both the systolic and diastolic blood pressures along with a decrease in the total peripheral resistance of the circulatory system.  The lower total peripheral resistance results in a decrease of afterload on the heart, thus decreasing the workload on the heart as well as increasing the total cardiac output which is inversely proportional to the total peripheral resistance. The blood pressure lowering effect of PFB is dose-dependent.

Additional studies in rabbits show multiple physiologic effects of PFB Complex (PFBc) which inhibits the progression of atherosclerosis in rabbits fed a high lipid diet. The PFB Complex inhibits the deposition of lipid in the arterial wall as evidenced by a significant decrease of fatty streaks and atherosclerotic plaque in the vessels. Furthermore, the PFBc also prevents the formation of fibrous plaques in the arterial wall and substantially increases the number of arteries which are free of any atherosclerotic lesion.

The  Palm Fruit Bioactives Complex™ contains 5 unique Polyphenols:

  • protocatechuic acid,
  • p-hydroxybenzoic acid, and
  • 3-O-caffeoylshikimic acid
  • 4-O-caffeoylshikimic acid
  • 5-O-caffeoylshikimic acid

These signature polyphenols have never been available in the nutraceutical market until now. The Palm Fruit Bioactive Complex is produced with a patented isolation technology in a state-of-the art manufacturing facility under food GMPs.