The beta amyloid peptide appears to play a key role in the decrease of brain function over time. The aggregation of the β-amyloid peptide into oligomers and the formation of fibrils appear to be key events in the reduction of brain function. Soluble oligomers of the β-amyloid peptide are neurotoxic and can cause neuronal cell death.
In several pre-clinical research studies in animals, PFB Complex (PFBc) has been shown to inhibit β-amyloid aggregation. The marked inhibitory effect of PFBc on β-amyloid aggregation has been demonstrated by: the Congo Red dye binding assay, Mass Spectrometry assays of aggregated peptide, and by 2-D Infrared spectroscopy. Based on these studies, PFBc holds promise as a nutritional aid to good brain health.