OUR PRODUCT

The Palm Fruit Bioactives Complex (PFBc)

The Palm Fruit Bioactives Complex is a 100% natural, non-GMO, water-soluble complex derived from the fruit of the oil palm tree. The complex is biologically active with very strong antioxidant, anti-inflammatory and immune modulation activity based on research in animals.* Palm Fruit Bioactives are composed of natural polyphenols, soluble fibers, protein and sugars. These ingredients have evolved over millions of years to preserve and protect the oil palm tree and its fruit. Phenolaeis is bringing this natural plant complex to the market for the first time. Phenolaeis’ proprietary isolation technology preserves this unique material and is fully sustainable and environmentally friendly.

* These statements have not been evaluated by the Food and Drug Adminstration. These products are not intended to diagnose, treat, cure or prevent any disease.

Palm Fruit Bioactives are available in a powdered and liquid form.

The  Palm Fruit Bioactives Complex contains 5 unique Polyphenols:

  • protocatechuic acid,
  • p-hydroxybenzoic acid
  • 3-O-caffeoylshikimic acid
  • 4-O-caffeoylshikimic acid
  • 5-O-caffeoylshikimic acid

These signature polyphenols have never been available in the nutraceutical market until now. The Palm Fruit Bioactive Complex is produced with a patented isolation technology in a state-of-the art manufacturing facility under food GMPs.

Supply

The Palm Fruit Bioactives Complex will be produced at our PFB Isolation Facility which is co-located at our Uumbal partners’ Plantation and Mill facilities in Chiapas, Mexico. The oil palm plantation has RainForest Alliance certification. The plantation will provide the starting material used in our 100% natural and sustainable Palm Fruit Bioactives manufacturing process. In 2017 our Uumbal partners completed construction of a state-of-the art sustainable Oil Palm Mill that is now operational. We have begun construction and anticipate our PFB Isolation Facility to be complete in Q4 2018. Both facilities will be operated according to strict quality standards under food GMP guidelines.

Safety

Palm Fruit Bioactives has self-affirmed GRAS Status. We are currently finalizing our GRAS documentation for filing with the FDA.

An Abstract on the Safety Results of water-soluble Palm Fruit Bioactives can be found below:

Barry S. Lynch, Spencer West, Ashley Roberts

Intertek Scientific & Regulatory Consultancy, 2233 Argentia Road, Suite 201, Mississauga, Ontario, L5N 2X7, Canada

Water-soluble palm fruit bioactives, derived from the aqueous stream of palm oil processing, have shown anti-diabetogenic effects in rodent models. To assess the safety of potential incorporation of this polyphenol-containing material in food, in vitro bacterial reverse mutation and in vitro chromosome aberration assays were conducted along with a 90-day sub-chronic toxicity study in Sprague-Dawley rats.  Water-soluble palm fruit bioactives were inactive in the Ames and in vitro chromosome aberration assays up to the limit doses of 5000 mg/plate and 5000 mg/mL, respectively. In the 90-day feeding study, water-soluble palm fruit bioactives were administered via gavage at doses 0, 500, 1000 or 2000 mg/kg body weight/day. No significant effects were noted on body weight, food consumption, hematology, clinical chemistry, organ weights, and histopathological examination. The No Observable Adverse Effect Level was considered to be 2000 mg/kg body weight/day, the highest dose tested. These data provide evidence to support the safe use of water-soluble palm fruit bioactives in food or food ingredients.

© 2017 Elsevier Inc. All rights reserved.

B.S. Lynch et al. / Regulatory Toxicology and Pharmacology 88 (2017) 96e105

An FDA reviewed GRAS Status filing is planned.

Supply

The Palm Fruit Bioactives Complex will be produced by Phenolaeis Mexico at our wholly owned isolation facility. Phenolaeis Mexico is a Joint Venture Partnership with Entorno Agroforestal and Evergreen Health. The Palm Fruit Bioactives isolation facility will be co-located at our oil palm plantation, which is RainForest Alliance certified. The plantation will provide the starting material used in our 100% natural and sustainable Palm Fruit Bioactives manufacturing process. Our brand-new state of the art Palm Fruit Bioactives facility will be operated according to strict quality standards under food GMP guidelines.

Safety

Palm Fruit Bioactives will have self-affirmed GRAS Status.

An Abstract on the Safety Results of water-soluble Palm Fruit Bioactives can be found below:

Barry S. Lynch, Spencer West, Ashley Roberts

Intertek Scientific & Regulatory Consultancy, 2233 Argentia Road, Suite 201, Mississauga, Ontario, L5N 2X7, Canada

Water-soluble palm fruit bioactives, derived from the aqueous stream of palm oil processing, have shown anti-diabetogenic effects in rodent models. To assess the safety of potential incorporation of this polyphenol-containing material in food, in vitro bacterial reverse mutation and in vitro chromosome aberration assays were conducted along with a 90-day sub-chronic toxicity study in Sprague-Dawley rats.  Water-soluble palm fruit bioactives were inactive in the Ames and in vitro chromosome aberration assays up to the limit doses of 5000 mg/plate and 5000 mg/mL, respectively. In the 90-day feeding study, water-soluble palm fruit bioactives were administered via gavage at doses 0, 500, 1000 or 2000 mg/kg body weight/day. No significant effects were noted on body weight, food consumption, hematology, clinical chemistry, organ weights, and histopathological examination. The No Observable Adverse Effect Level was considered to be 2000 mg/kg body weight/day, the highest dose tested. These data provide evidence to support the safe use of water-soluble palm fruit bioactives in food or food ingredients.

© 2017 Elsevier Inc. All rights reserved.

B.S. Lynch et al. / Regulatory Toxicology and Pharmacology 88 (2017) 96e105

An FDA reviewed GRAS Status filing is Planned.

These publications highlight the scientific information on Palm Fruit Bioactives

These publications highlight the scientific information on Palm Fruit Bioactives

These publications highlight the scientific information on Palm Fruit Bioactives

(a.k.a oil palm phenolates, OPP)

  1. Composition and Method for Improving Vascular Health. US Patent Application 20120141612.
  2. Compositions Comprising Extracts Obtained From Oil Palm Based Materials for Providing Anti-Inflammatory Effects and Method of Producing Thereof. Malaysia. 2010005402.
  3. Methods for the Treatment or Prevention of Diabetes Mellitus and Other Metabolic Imbalances. USA. 8,071,143.
  4. Balasundram, N., T. Y. Ai, et al. (2005). “Antioxidant properties of palm fruit extracts.” Asia Pac J Clin Nutr 14(4): 319-324.
  5. Chaabo, F., A. Pronczuk, et al. (2010). “Nutritional correlates and dynamics of diabetes in the Nile rat (Arvicanthis niloticus): a novel model for diet-induced type 2 diabetes and the metabolic syndrome.” Nutr Metab (Lond) 7: 29.
  6. Christian A. (2008).  “Household dietary practices and family nutritional status in rural Ghana, Nutrition Research and Practice 2(1), 35-40.
  7. Leow, S. S., S. D. Sekaran, et al. (2011). “Differential transcriptomic profiles effected by oil palm phenolics indicate novel health outcomes.” BMC Genomics 12: 432.
  8. Leow, S. S., S. D. Sekaran, et al. (2013). “Oil palm phenolics attenuate changes caused by an atherogenic diet in mice.” Eur J Nutr 52(2): 443-456.
  9. Leow, S. S., S. D. Sekaran, et al. (2013). “Oil palm phenolics confer neuroprotective effects involving cognitive and motor functions in mice.” Nutr Neurosci 16(5): 207-217.
  10. Noda, K., M. I. Melhorn, et al. (2010). “An animal model of spontaneous metabolic syndrome: Nile grass rat.” FASEB J 24(7): 2443-2453.
  11. Nyangasa MA, (2011) Nutrition status of Ghanaian Women with Young Children-dietary Intake, Anthropometric and Life Style Data. MS thesis (Hamburg Univ.).
  12. Sambanthamurthi, R., Y. Tan, et al. (2011). “Oil palm vegetation liquor: a new source of phenolic bioactives.” Br J Nutr 106(11): 1655-1663.
  13. Sambanthamurthi, R., Y. Tan, et al. (2011). “Positive outcomes of oil palm phenolics on degenerative diseases in animal models.” Br J Nutr 106(11): 1664-1675.

				

Intellectual Property

The Intellectual Property filings for Palm Fruit Bioactives is broad and extensive with over 23 Internationally filed and issued patents. Phenolaeis licensed the rights to all current and future patents in 2011. The Intellectual Property Patent estate covers the manufacturing process for Palm Fruit Bioactives, composition of matter for antioxidant compounds and various methods of use.

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